Polymer-ka dahaarka ee Hypromellose Acetate Succinate (HPMC AS)
sharraxaad1
Sharaxaadda Badeecada
Hypromellose Acetate Succinate (HPMC AS) waa polymer cellulose ah oo wax laga beddelay oo si weyn loogu isticmaalo qaacidooyinka daawada sida walxo dahaarka enteric. Waxay bixisaa ilaalin lagu kalsoonaan karo oo loogu talagalay maaddooyinka firfircoon ee ka dhanka ah aashitada caloosha iyadoo u oggolaanaysa kala dirida jawiga mindhicirka. Iyada oo leh awood filim sameynta oo heer sare ah iyo tayo joogto ah, HPMC AS waxay taageertaa waxqabadka dahaarka deggan ee wax soo saarka kiniiniga iyo kaabsal ee casriga ah. Milmigeeda la xakameeyey wuxuu gacan ka geystaa kor u qaadista xasilloonida daawada iyo astaamaha sii deynta ee la beegsanayo. Maaddadu waxay la jaanqaadaysaa noocyo badan oo ah maaddooyinka daawada firfircoon iyo walxaha dheeraadka ah, taasoo ka dhigaysa doorasho la doorbido qaababka qiyaasta sii deynta dib loo dhigay iyo nidaamyada keenista daawada afka ee horumarsan.
Halbeegyada Farsamada
| Shay | Heerka Caadiga ah |
| Imtixaanka Dareenka | Budada ama budada huruud khafiif ah ilaa caddaan ah |
| Viscosity | 2.4-3.6 mp.s |
| Lumis marka la qalajiyo | ≤5.0% |
| Haraaga shidista | ≤0.2% |
| Biraha Culus | ≤10PPM |
| Aashitada acetic iyo aashitada succinic bilaash ah | ≤1.0% |
| Waxyaabaha acetyl ka kooban | 5.0~9.0% |
| Waxyaabaha ku jira Succinyl | 14.0~18.0% |
| Waxa ku jira Methoxy | 20.0~24.0% |
| Waxyaabaha ku jira Hydroxypropoxy | 5.0~9.0% |
Faa'iidooyinka Alaabta / Codsiyada
● Ilaalinta Aashitada u Adkeysata– Waxay ka hortagtaa sii deynta maaddooyinka xasaasiga ah ee caloosha ku jira waqti hore.
● Kala-baxa Mindhicirka ee Bartilmaameedsan– Waxay awood u siisaa sii deynta daawada xiidmaha yar si loo hagaajiyo nuugista.
● Samaynta Filimada Isku-midka ah– Waxay soo saartaa lakabyo dahaadh siman oo joogto ah oo ku yaal kiniiniyada ama kaabsulka.
● Waxqabadka Habaynta Lagu Kalsoonaan Karo- Ku habboon teknoolojiyada kala duwan ee dahaarka iyo hababka qaabaynta.
● Dabacsanaanta Qaaciddada- La jaan qaada API-yo badan iyo daawooyinka kaabayaasha ah.
● Xasillooni La Hagaajiyay– Waxay taageertaa cimriga shelf-ka badeecada oo wanaagsan waxayna ilaalisaa qaybaha firfircoon inta lagu jiro kaydinta.
Codsiyada Caadiga ah & Qiyaasta lagu taliyay
| Aagga Codsiga | Nooca Badeecada | Diiradda Codsiga | Qiyaasta Caadiga ah* |
| Kiniiniyada Daawada | Polymer-ka dahaadhka ee Enteric | Ilaali daawooyinka xasaasiga u ah aashitada iyo xakamaynta sii deynta xiidmaha | 4–8% xalka dahaarka |
| Kaabsul adag | Dahaarka Filimka Enteric | Hagaajinta xasilloonida caloosha iyo mindhicirka iyo sii daynta dib u dhaca | 3–7% qaabka dahaarka |
| Foomamka Qiyaasta Afka ee Adag | Daawada Daawaynta ee Shaqada leh | Kala dirista la xakameeyey iyo hagaajinta keenista daawada | 2–6% wadarta guud ee qaacidada |
| Kiniiniyada Nafaqada | Wakiilka Dahaarka Ilaalinta | Ka ilaali nafaqooyinka firfircoon aashitada caloosha | 3–6% nidaamka dahaarka |
| Qaacidooyinka Sii-deynta Dib-u-dhaca ah | Polymer-ka sii daynta ee la xakameeyey | Kobcinta gaarsiinta xiidmaha ee la beegsanayo | 2-5% iyadoo ku xiran qaacidada |
* Qiyaasta daawada way kala duwanaan kartaa iyadoo ku xiran xaaladaha gaarka ah ee diyaarinta iyo habaynta.
Baakadaha Alaabta
Badeecada waxaa lagu shubay fuusto fiilooyin ah oo 15 kg ah oo shaabadaysan si loo hubiyo ilaalinta qoyaanka iyo wasakhowga inta lagu jiro kaydinta iyo rarista. Durbaan kasta waxaa si taxaddar leh loogu dahaadhay bacaha gudaha ee ilaalinta si loo ilaaliyo tayada iyo xasilloonida badeecada inta lagu jiro geeddi-socodka rarista iyo maaraynta adduunka oo dhan.
Hel Qiimayn